The sixth meeting in the Chemical and Biological Medical Treatment Symposia (CBMTS) series and the third international meeting to be held at the original venue of the CBMTS, the AC-Laboratorium Spiez (ACLS), Switzerland.

The CBMTS III

Spiez, Switzerland, 7-12 May 2000. Over 100 professionals in medicine, science and related disciplines from 32 countries will be representing goverment, academia and industry at this exceptionally important and timely symposium. The quality of papers, as well as the expertise of the presenters, when combined with the normal enthusiasm of the CBMTS members, will make for another lively, informative symposium - another great CBMTS meeting.

On behalf of all CBMTS members, ASA and the CBMTS International Organizing Committee would like to thank Dr. Bernhard Brunner, Director ACLS, and the Swiss Federation for their continuing support of the CBMTS as a method in bringing together from east and west, north and south, the professionals in science and medicine to share knowledge and friendship. This sharing between the CBMTS professionals has produced documented results that we feel may have also contributed very much to understanding and peace. And all of us want to thank the Swiss CBMTS Organizing Committee for a job well done. They did a great job.



Welcome to the AC-Laboratorium Spiez (ACLS) from Dr. Bernhard Brunner, Director ACLS and CBMTS-III, Dr. Rudolf Portmann, Co-Director CBMTS-III, Dr. Barbara Price, Co-Chair CBMTS-III, and Dr. Ueli Huber, Deputy Director ACLS and Chair CBMTS Organizing Committee.
The AC-Laboratorium Spiez. Looking at a portion of the main laboratory and headquarters building. Niessen is the mountain in the background.

The following is a list of the papers and posters presented in Spiez.

A picture of the group is on the web.

The Technical Agenda CBMTS III

Sector Chemical Aspects:

Chair: Rudolf Portman

Co-Chair:David Moore

Sessions: 1, 2, 4, 5, 8, 9, 10, 11, 13, 15

Sector Biological Aspects:

Chair Scott Lillibridge

Co-Chair: Ji-Sheng chen

Sessions: 3, 6, 7, 12, 14, 16

The meeting ran from Sunday 7 May to Friday 12 May, 2000.

A review of the meeting will be presented in the next ASA Newsletter, Issues #78, June 29, 2000.

For information on the next CBMTS meeting, go to CBMTS Industry II: The First World Congress on Chemical and Biological Terrorism

COUNTRY NAME TITLE No. SESSION
AUSTRALIA Robertson, A.G. Bioterrorism and Australia - The Way Ahead

1

3
BRAZIL Santana, G. Communication in the Heat of a Crisis - The Crucial Element for Effective Crisis Decision Making

2

16
CANADA Eaton, D. Mass Casualty Decon and Olympic Style NBC Response Factors and Solutions for CB Related Events

7

11
CANADA Hamilton, M "Hinge" Peptide Libraries as Inhibitors of Botulinus Neurotoxin

8

6
CANADA Harwood, C. Canada’s Response To NBC Incidents

9

3
CANADA Laurie, E. Gloves that Fit and Do NOT Tear: a Novel Idea.

10

11
CANADA O'Dell, P. Recent and Planned Research to Extend and Further Validate RDSL as a Broad Spectrum Personal Decontaminant System for BCW Agent Decontamination

6

11
CANADA Pitts, N. Large Scale Mass Decontamination and Special Event Planning Criteria for Special International Events based on the CASCAD System and Canadian Model

7

11
CANADA Tremblay-Lutter, J. Gloves that Fit and Do NOT Tear: a Novel Idea.

10

11
CHINA Chen, JiSheng An Assessment of Toxins

11

6
CHINA Zhang, Y. Effects of some Reversible Cholinesterase Inhibitors on the Reactivatability of Soman-inhibited Human Erythrocyte Acetylcholinesterase in vitro.

12

4
CHINA Zhou, W. Effects of some Reversible Cholinesterase Inhibitors on the Reactivatability of Soman-inhibited Human Erythrocyte Acetylcholinesterase in vitro.

12

4
CROATIA Bokan, S. Criteria for Selection of Human, Animal and Plant Pathogens and Toxins to be Included in a List of Biological Agents and Toxins in Relation to the BTWC

13

7
CROATIA Bokan, S. Scientific Review of CBMTS - Industry I

14

INTRO
CROATIA Orehovec, Z. Operational Review of CBMTS - Industry I

16

INTRO
CROATIA Reiner, E. Acetylcholinesterase and Butyrylcholinesterase Activity Measurements in Human Blood by the Ellman Method: Procedure Protocol and Comparison with Procedures Suggested by Other Authors

17

10
CROATIA Reiner, E. State of the Art Lecture: Organophosphorus Compounds and Esterases: Current Research Topics Concerning Toxicity of and Protection Against Organophosphates

18

1
CROATIA Simeon, V. Acetylcholinesterase and Butyrylcholinesterase Activity Measurements in Human Blood by the Ellman Method: Evaluation of Experimental Conditions

19

2
CZECH REPUBLIC Bajgar, J. Inhalation Intoxication with Sarin: Relationship between Sarin Dose and Cholinesterase Inhibition in Blood

21

13
CZECH REPUBLIC Bajgar, J. Simple Method for More Precise Diagnosis and Treatment of Intoxication with Nerve Agents Poisoning

22

1
CZECH REPUBLIC Kassa, J. The Long-term Effects of Low Level Inhalation Exposure of Rats to Sarin

23

13
FRANCE Dorandeu, F. Search for New Neuroprotective Drugs Against Soman-Induced Central Neuropathology: Antioxidants

26

2
GEORGIA Juruli, M. On the Old Military "Heritage" in Georgia

28

13
GEORGIA Juruli, M. Toxicological Aspects of Events in Tbilisi on April 9, 1989

29

9
GERMANY Eyer, P. The Determination of Human Erythrocyte Acetylcholinesterase (ERY-ACHE) in a Modified Ellman Assay

30

10
GERMANY Müller-Amato, L. Mass Casualty Decon and Olympic Style NBC Response Factors and Solutions for CB Related Events

7

11
GERMANY Sierchermann, K. Mass Casualty Decon and Olympic Style NBC Response Factors and Solutions for CB Related Events

7

11
GERMANY Szinicz, L. Sulfur Mustard Induced Cytokine Changes in Different Cell Cultures

31

5
GERMANY Worek, F. New Aspects on the Reactivation by Oximes of Organophosphate-Inhibited Human Acetylcholinesterase in vitro

32

1
INDIA Jaiswal, D. Prophylactic Efficacy of Amifostine and its Analogues against Sulphur Mustard Intoxication

33

5
IRAN Balali-Mood, M. Effects of Sodium Bicarbonate in Human Organophosphate Poisoning

34

1
IRAN Haghighi, L. A Review of Infections Among Iranian Combatants in the Iran-Iraq War

35

12
IRAN Kalantari, H. Identifcation and Determination of Mycotoxins by HPLC in Liver

36

6
ISRAEL Wormser, U. Iodine Protects Skin Against Mustard Gas

37

5
KAZAKHSTAN Lepeshkin, G. Conversion of Biotechnology (BW) Complex in Kazahstan: Scientific and Technical. The New Results

38

7
KENYA Mathenge, V. Mass Casualty Management in the Event of a Chemical Accident

39

8
MACEDONIA Taleski, V. Epidemiology and Detection Methods of the Most Important Infectious Diseases in the Republic of Macedonia

40

7
NETHERLANDS Davey, B. Biomedical Sampling: An OPCW Perspective.

41

9
NETHERLANDS Nieuwenhuizen, M. Physostigmine as a Pretreatment Against Soman-Intoxication Under Stress Circumstances

42

4
NETHERLANDS Noort, D Methods for Retrospective Detection of Exposure to Toxic Scheduled Chemicals: An Overview

43

9
NETHERLANDS Philippens, I. Physostigmine As A Pretreatment Against Soman-Intoxication Under Stress Circumstances

42

4
PAKISTAN Khan, L.A. Non-Conventional Terrorism: Threat and Countermeasures

44

3
POLAND Kowalczyk, M. Imidazenil, a Proposed Drug for the Treatment of Convulsions in Acute Poisonings with Soman

46

5
POLAND Rump, S. Imidazenil, a Proposed Drug for the Treatment of Convulsions in Acute Poisonings with Soman

46

5
ROMANIA Mircioiu, C. Pharmacokinetic Component of the Mechanism of Action of Decorporators

47

5
ROMANIA Paul, F. Epidemiological Approach of Biological Crisis Caused by Criminal Use of Bacillus Anthracis

48

7
RUSSIA Petrov, V. Creation of Modern Systems of Warning of Population and Personnel During Emergency at the Sites of Chemical Weapons Storage and Destruction in Russia

49

13
RUSSIA Ryabchikova, E. Virus Reproduction in Macrophages: A Common Feature of Viral Hemorrhagic Fevers

50

7
RUSSIA Shchelkunov, S. N. Smallpox, Monkey pox, and Cowpox Viruses as Sources of New Therapeutic Drugs

51

12
RUSSIA Surovtsev, I. Scanning Flow Cytometry for Kinetics Study of Antigen-Antibody Interaction on the Cell Surface

52

9
RUSSIA Tonkopii, V. Structure and Efficiency of Carbamates as Drugs for Prophylaxis

53

4
SINGAPORE Moochhala, S. Effects of Pyridostigmine (PYR) and non-Penetrative Head Injury of Neuromuscular Performance in the Rat

20

4
SOUTH AFRICA Erasmus, C. Compilation of a Training Curriculum for CB Defense Specialist Advisers for the South African National Defence Force

58

3
SOUTH AFRICA Yousefi, V. Agrochemicals: A Toxic Terror In South Africa

59

14
SPAIN Pita, R. The Spanish Armed Forces Autoinjector for Nerve Agent Antidote

60

13
SWEDEN Persson, S.A. Decontamination Of Casualties After Exposure To Harmful Liquid Chemicals

61

11
SWITZERLAND Baumberger, Ch. Risk Assessment of Bioterrorism

56

16
SWITZERLAND Brodbeck, U. Evaluation of Methods for Interlaboratory Comparison Tests on Measurements of Cholinesterase Activity

62

10
SWITZERLAND Centonze, A. Swiss Protection Equipment Training and Availability

57

16
SWITZERLAND Huber, U. The Swiss Approach to Counter Chemical Terrorism

63

14
SWITZERLAND Portmann, R. Towards a Common Method for Measuring Cholinesterase Activity

64

10
SWITZERLAND Robinson, S. Monitoring Of Potential Health Effects Of Nerve Agent Destruction In Shchuch'ye, Kurgan Oblast (South Ural), Russian Federation

65

13
SWITZERLAND Schuerch, N. Immunodetection of Biological Agents by Repertoire Cloning

66

14
SWITZERLAND Schuetz, M. Current Developments in Gene Technology: The Impact on Biological Weapons

67

7
SWITZERLAND Wicki, A. Capsaicin in Pepperspray - Mode of Action

68

9
TURKEY Hincal, A. Mass CasualtyManagement in Turkish Pharmaceutical Industry

69

8
TURKEY Hincal, F. The Role of Drug and Poison Information Centers in Emergency Assistance and Professional / Public Education for CBW

70

8
TURKEY Ozyurt, G. Role of Serum Cholinesterase Activity in the Treatment of Organophosphate (OP) Intoxication

71

1
UKRAINE Chaika,Y. Minimizing the Ecological Consequences of Chemical Agent Destruction

88

13
UNITED KINGDOM McMillan, M. R. Overview of Plague Vaccine

24

12
UNITED KINGDOM Russell, P. Overview of Plague Vaccine

24

12
UNITED KINGDOM Scott, L. Assessing the Effects of Low Level Anticholinesterases

25

1
USA Broomfield, C. Kinetics of Nerve Agent Hydrolysis by a Human OPAA Hydrolase

72

15
USA Cheng, T-C. Wide Range Application of Alteromonas Prolidase for Decontamination of G-Type Chemical Nerve Agents

73

15
USA Doctor, B. Buforin I, a Natural Peptide, Inhibits Botulinum Toxin B Activity

74

14
USA Doctor, B. Scavenger Protection Against Organophosphorus Agents by Cholinesterases

75

15
USA Doctor, B. Cholinesterases, Oximes, and Organophosphorus Hydrolases in Tandem Can Hydrolyze Organophosphates

84

13
USA Feaster, S. Rapid, Quantitative, and Simultaneous Determination of AChE and BChE Levels in Unprocessed Whole Blood

76

10
USA Filer, S. Novel Strategy Using Synthetic Nucleic Acids and Conventional Immunoassays for Biological Agent Detection

77

7
USA Gordon, R. Polyurethane Foam Linked Mammalian Cholinesterase for Decontamination and Detection of OP Nerve Agents

78

11
USA Hughart, J. Chemical Disaster Training For First Responders

79

8 or 13
USA Kosnett, M. The Role of Poison Control Centers and Medical Toxicologists in Responding to Chemical and Biological Incidents

80

8
USA Laughlin, L. History and Technological Evaluation of The U.S. Bio/Toxin Detection Program

81

6
USA Lindsey, K.Q. The Development of Both Laboratory Protocols for Identifying Bioterrorist Threat Agents and A National Network for Information Dissemination to State Public Health Laboratories In the United States

83

16
USA Melling, J. Biodefense Vaccines: Regulatory and Manufacturing Issues and Constraints

55

12
USA Moore, D. Applications of an Effective Biocidal Technology for Medical Defense Purposes

85

12
USA Petrikovoics, I. Diisopropylfluorophosphate (DFP) Antagonism by Recombinant Organophosphorus Acid Anhydrolase (OPAA) Encapsulated within Sterically Stabilized Liposomes (SL)

86

15
USA Rao, V. Long-Term Toxic Effects: Emerging New Challenges to Chemical Biological Risk Analysis and Medical Treatment Strategies

87

8
USA Rotz, L. Prioritizing Potential Biological Terrorism Agents for Public Health Preparedness in the United States: Overview of Evaluation Process and Identified Agents

89

16
USA Saxena, A. Recombinant Cholinesterases: Developing an Ideal Bioscavenger for Protection against Organophosphate Nerve Agents

90

15
USA Spies, S. WMD Casualty Planning

91

3
USA Treadwell, T. Electronic Syndromic Surveillance for Bioterrorism at the World Trade Organization Ministerial Conference in Seattle, Washington, 2000

92

16
USA Way, J. Antagonism of Organophosphorous Lethality with Sterically Stabilized Liposomes (Sl) Containing Recombinant Organophosphorus Acid Hydrolase (OPH)

93

15
YUGOSLAVIA Antonijevic, B. Efficacy of Oximes and Adamantanes against Soman Poisoning in Mice

94

2
YUGOSLAVIA Antonijevic, B. Memantine Treatment Improves Antidotal Efficacy of Atropine, HI-6 and Diazepam in Rats Poisoned with Soman

99

2
YUGOSLAVIA Dobric, S. The Protective Efficacy Of Calcium Channel Blockers In Soman-Poisoned Rats

95

4
YUGOSLAVIA Jovanovic, Dj. Efficacy of various corticosteroid regimens in treatment of acute T-2 toxin poisoning in rats. presented by Dr. Djordje Jovanovic

100

14