The 14 year anniversary of the Chemical and Biological Medical Treatment Symposia (CBMTS)




Spiez Laboratory

The Seventh Plenary


Spiez , Switzerland
13 April - 18 April 2008

The Technical Program


Sunday 13 April 2008

Participants arrive at the hotels in Interlaken

13.00                 Buses pick up participants at hotels in Interlaken for special training session
13.30 - 16.30    Special training session
16.30                 Buses return to Interlaken
17.00 - 18.30    Registration in Hotel Metropole
18.00 - 18.30    Meeting of session chairs and co-chairs
18.30 - 20.00    Welcome party


Monday 14 April 2008

08.10                  Buses leave from the hotels in Interlaken

Opening Ceremony CBMTS VII

09.00 - 10.00    Opening of Meeting:

  • Dr. Marc Cadisch, Symposium Director, Director SPIEZ LABORATORY
  • Maj. Gen. Jan Pietro Lupi, The Surgeon General, Swiss Army
  • Col. Richard Price, Symposium Co-Director
  • Introductions for the CBMTS VII Symposium Chair Dr. Brian Davey M.D. and Symposium Co-Chair Dr. Barbara Price
  • Dr. Brian Davey, Medical Director, United Nations (1)
    Chairman’s Address: From Proliferation to Pandemics: some thoughts from the Chair

10.00 - 10.30    Coffee break

Session 1  Overview on CBMTS VII

Chair: Jerome Donlon
Co-Chair:  Christian Griot

10.30 - 12.30

  • Griot, Christian (2)
    The Pirbright laboratory accident; what went wrong? (Contribution from Sector 6)
  • Donlon, Jerome (3)
    Strategic Considerations for Public Health Emergencies (Contribution from Sector 3)
  • Pellmar, Terry (4)
    Current Research in Radiation Biodosimetry (Contribution from Sector 3)
  • Holt, David (5)
    The Lethal Poisoning by Polonium of Mr. Alexander Litvinenko: Some Observations on Events following his Death based on Limited but Personal Experiences (Contribution from Sector 3)
  • Netesov, Sergey (6)
    Emerging Infections in the Asian Part of Russia (Contribution from Sector 2)
  • Tresnaningsih, Erna (7)
    Avian Influenza Transmission in Indonesia (Contribution from Sector 2)

Note: Above (Sector #) indicates Sector responsible for individual participant from this Opening Session

12.30 - 13.30    Lunch

Session 2  Chemical Aspects I 

Chair: Bhupendra Doctor
Co-Chair: Jiri Kassa

13.30 - 15.10

  • Doctor, Bhupendra (8)
    Current Status of the Use of Bioscavengers for Protection Against Chemical Warfare Agents
  • Saxena, Ashima (9)
    Developing A Broad-Spectrum Oxime For The Treatment Of Nerve Agent Toxicity
  • Chilukuri, Nageswararao (10)
    Development of Recombinant Human Butyrylcholinesterase as a Bioscavenger of Organophosphorus Nerve Agents
  • Kassa, Jiri (11)
    A Comparison of the Therapeutic and Reactivating Efficacy of Newly Developed Bispyridinium Compounds (K206, K269) with Currently Available Oximes Against Tabun in Rats and Mice
  • Kuca, Kamil (12)
    Structure-activity relationship of acetylcholinesterase reactivators
  • Musilek, Kamil (13)
    Novel reactivators of AChE with (E)-but-2-ene linker – rivals for obidoxime?

15.10 - 15.40    Coffee break

Session 3  Crisis Management I

Chair: Gudrun Cassel
Co-Chair: Timothy Bauer

15.40 - 17.30

  • Baud, Frédéric (14)
    Preparedness in France towards the cyanide risk      
  • Bauer, Timothy (15)
    Employment of a New Approach for Estimating Hazards Resulting from a Massive Chlorine Release      
  • Cassel, Gudrun (16)
    Development of generic scenarios for release of chemicals by terrorist as a tool for crisis management teams and Public Health      
  • Nolan, Richard (17)
    US National Veterinary Stockpile: Logistics Expertise Improving Animal Disease Response
  • Ramabrahmam, Boppana (18)
    Chemical Process Risk Analysis – An Overview

17.40                 Buses leave to Interlaken
19.00                 Dinner at Hotel Metropole


Tuesday 15 April 2008

07.45                 Buses leave from the hotels in Interlaken

Session 4  Chemical Aspects II

Chair: Urs Brodbeck
Co-Chairs: Ashima Saxena,
Kamil Kuca

08.30 - 10.00

  • Kannan, Mathu (19)
    Development of antidote for blistering agents: Sulphur and Nitrogen Mustard
  • Orehovec, Zvonko (20)
    The Future of the OPCW after Chemical Weapons Destruction

Presentation of posters on chemical and biological aspects:

  • Bajgar, Jiri (21)
    Cholinesterase Reactivators: Mapping of their Effect in the Rat Brain  (Toxicological, Biochemical and Histochemical Study)
  • Jun Daniel (22)
    Reactivation of Human Acetylcholinesterase Inhibited by Leptophos-oxon with Different Oxime Reactivators In Vitro
  • Karasova, Jana  (23)
    Pretreatment with Huperzine A Protects Acetylcholinesterase in the Rat Brain Against Inhibition by Soman, VX And Russian VX In Vivo
  • Kuca, Kamil  (24)
    Acetylcholinesterase reactivator – oxime HI-6 – antidote against nerve agents
  • Sinko,  Goran (25)
    Comparison of pyridinium aldoximes in their reaction with the cholinesterase substrate acetylthiocholine
  • Zdanowski, Robert (26)
    Evaluation of the Chosen Parameters of Cancerous Angiogenesis in Mice after Isopropyl-Methylphosphonofluoridate Administration
  • Savel’eva, Elena (27)
    Determination of the Composition of Degradation Products of Russian VX In Various Media
  • Koryagina, Nadezhda L. (28)
    Application of Solid-Phase Microextraction ror GCMS Analysis of Terrorist Poisons
  • Özyurt, Gürayten (29)
    Mechanisms of Some Poisons Used Today and in the Past History
  • Ramabrahmam, Boppana (30)                       
    Advances in Science and Technology and the Impact of these Developments on the Chemical Weapon Convention (CWC)
  • Sardas, Semra (31)
    Arsenic problem in drinking water of developing countries
  • Dishovsky, Christophor (32)                                               
    Biological Markers of Intoxications with Nerve Agents

10.00 - 10.30    Coffee break with Viewing of Posters Session 4

Session 5  Special Interest

Chair: Timothy Henry
Co-Chair: Oliver Schirk

10.30 - 12.30

  • Henry, Timothy (33)
    What is wrong with the water?       
  • Schirk,  Oliver (34)
    Measurement of Biological Warfare Substances using a quick test system       
  • Wannarka, Gerald (35)
    The Auto-Injector as a Drug Delivery System        
  • Salmi, Hannu (36)
    Combined UV-fluorescence and Background Aerosol Monitoring for Detection of Intentional Release of Airborne Biological Agents        
  • Karalus, Richard (37)
    Disposable Integrated Microfluidic Microarray Tests for Simple to Use, Low Cost Identification of Infectious Agents
  • Abbott, Christopher (38)
    Real-Time Medical Surveillance

12.30 - 13.30    Lunch

Session 6  Medical Aspects

Chair: Stephen Borron
Hakan Yaren, Pascale Ribordy

13.30 - 15.50

  • Borron, Stephen (39)
    Intraosseous Administration of Antidotes in the Goat by Hazardous Materials Responders and Receivers 
  • Perino, Louis (40)
    Demonstrating the Emergency Treatment of WMD Agents on the METIMAN Patient Simulator
  • Stienstra, Stef (41)
    Intradermal Vaccination with a New ‘Tattoo’-Like Device Results in Faster Immunization
  • Nambiar, Madhusoodana (42)
    Medical Countermeasures against Respiratory Toxicity and Acute Lung Injury following Inhalation Exposure to Chemical Warfare Agents
  • Yaren, Hakan (43)
    Effects of Poly(ADP-RIBOSE) Polymerase Inhibition in Lung Toxicity Caused by Nitrogen Mustard in Rats

Presentation of posters on medical aspects

  • Baud, Frédéric (44)
    Cyanide poisoning and structural fires
  • Borron, Stephen  (45)
    Hemodynamics after Intraosseous administration of Hydroxocobalamin in the goat
  • Vucinic, Slavica  (46)
    Acute Organophosphate Poisoning: The Standard Therapy compared to Sodium Bicarbonate as a Therapeutic Agent
  • Dizaye, Kawa  (47)
    Hepatoprotective Effects of the Aqueous Extract of Pistacia Khinjuk on Acetaminophen and Carbon Tetrachloride - induced acute Liver Toxicity in Rat
  • Price, Barbara  (47)
    The On-Line Journal of Medical Chemical, Biological and Radiological Defense
  • Stephen, Eric  (48)
    Defence R&D Canada - current medical countermeasures
  • Lavigne, Jacques (49)
    Defence R&R Canada – Medical Countermeasures Program
  • Hadjamberdiev, Igor (50)
    Old  Uranium  Tails  in  Pamir

Presentation of posters on radiological aspects

  • Pivovarov, Alexander A. (51)
    Radiation Risk and Possible Consequences for Ukrainian Population
  • Jikida, David  (52)
    Medical Management Strategy of Patients with Local Radiation Injury During Acute Phase
  • Sezigen, Sermet (53)
    CB Pharmaceutical Stockpile For Emergency Services; GATA Preparedness
  • Ramabrahmam, Boppana (54)
    Model  Emergency / Disaster Management  Plan.  Case Study: Toxic Gas  Release from a Chemical Facility.

15.50 - 16.20    Coffee break with Viewing of Posters Session 6
16.30                 Buses leave to Interlaken
18.30                 Buses leave from the hotels for Symposium Dinner
19.00 - 23.00    Symposium Dinner


Wednesday 16 April 2008

07.45                 Buses leave from the hotels in Interlaken

Session 7  Biological Aspects 1

 Chair: Thomas Beacorn       
Co-Chairs: Erna Tresnaningsih,
Sumera Mahboob

08.30 - 10.20       

  • Beacorn, Thomas (55)
    The Food Emergency Response Network in the U.S.
  • Rao, Venkat (56)
    Converging Requirements and Emerging Challenges to Public Health Disease Surveillance and Biosurveillance
  • Weingart, Oliver (57)
    Threat of a Bioterror Attack on the Food Supply
  • Stipetic,  Davor (58)
    Evidence of Bio-Terrorism as Form and Method of Warfare

Presentation of posters on biological aspects:

  • Stephen, Eric (59)
    Defence R&D Canada’s Nucleic Acid-Based Anti-Viral Program  
  • Rudolf, Sandra Paniga  (60)
    Sero-Prevalence of Brucellosis in Kyrgyzstan
  • Kaonga, Kennedy (61)
    Trypanosomes in Africa: The Urgency of their Re-emergence

Presentation of posters on Detection and Decontamination

  • Gröflin, Rahael   (62)
    Evaluation of Immunological Detection Systems (ABICAP, Bioveris M1M, Bioplex 200, ABICAP and Sctor Imager  6000) Using Vaccinia Virus as a Model
  • Liu, Cheng-Che (63)
    Monoclonal Antibody-Based Lateral Flow Assay for Detection of Botulinum Neurotoxin Type A
  • Kalantari, Heibatullah (64)
    Acetylcholinesrase and Butrylcholinestrase Activities Measurements in Different Communities of Khosestan Province (Iran – Iraq War Region) Exposed to Organophosphate Compounds

Presentation of posters from Special Session and Emerging Threats

  • Nolan, Richard (65)
    Disaster Logistics: Important to Government Success, often Overlooked
  • Bokan, Slavko  (66)
    Counterproliferation of WMD, Border Security and Counter-terrorism (CBSC) in Southeastern Europe

10.20 - 10.50    Coffee break with Viewing of Posters Session 7

Session 8  Radiological Aspects

Chair: Francis Hérodin
Co-Chair: Steven Adams

10.50 - 12.50

  • Adams,  Steven (67)
    Innovative Radiological Countermeasure Strategies for Public Health, Emergency Response, and Medical Systems
  • Herodin, Francis (68)
    Current and New Approaches to the Treatment of Radiation Accident Victims
  • Hauer-Jensen, Martin (69)
    Gastrointestinal Radiation Injury: Significance, Mechanisms, and Countermeasures
  • Chelidze, Lia (70)
    Radiological Accidents Conditioned by Abandoned Orphan Sources in Georgia
  • Egger, Emmanuel (71)
    DU-Ammunition: A Threat to Civilian Population?
  • Smith, Darrin (72)
    Radiation Monitoring for Large Scale Events

12.50 - 13.40    Lunch

Session 9  Emerging Threats, Dual Use, BioSafety/BioSecurity I

Chair: Slavko Bokan
Co-Chair: Venkat Rao

13.40 - 15.00

  • Deneer, Harry (73)
    Developing a mechanism for the responsible communication of research having dual-use potential - An editor's and publisher's perspective      
  • Price, Barbara (74)
    The Promise and Threat of Nanotechnology      
  • Rao, Venkat (75)
    Biosecurity and Biosafety Assessment and Enabling Technologies in Support of the Biodefense R&D Facilities
  • Schütz, Martin (76)
    Hands-On Biosafety/Biosecurity Training in a Fully Functional BSL4 Environment: The Spiez Laboratory Concept      
  • Dudley, Joseph (77)
    Zoonotic and Emerging Diseases Surveillance: A Global Biosecurity Imperiti

15.00 - 15.30    Coffee break with Posters Viewing
15.30 - 16.00    Group Photo
16.00 - 17.30    Tour of SPIEZ LABORATORY
16.15                 Buses leave to Interlaken
17.45                 Buses leave to Interlaken
19.00                 Dinner at Hotel Metropole


Thursday 17 April 2008

07.45                 Buses leave from the hotels in Interlaken

Session 10  Crisis Management II   
A Special US EPA Risk Assessment Session

Chair: Deborah McKean
Co-Chairs: Tonya Nichols,
Florin Paul

08.30 - 10.20

  • Bice, Steven
    Introduction and overview      
  • McKean, Deborah (78)
    Evaluation of Human Health Risks of Indoor Chemical Contaminants Before and After Decontamination      
  • Nichols, Tonya (79)
    Risk-based Assessment and Management Activities for Responding to the Release of a Biothreat Agent      
  • Taylor, Michael (80)
    SERRA: The Use of a Knowledgebase Approach to Meet the Needs of Pre-Event Planning and Post-Event Consequence Management
  • Paul, Florin (81)
    Crisis Management in an International Environment with an International Organization
    Round table/panel discussion

10.20 - 10.50    Coffee break with Poster Viewing

Session 11  Detection and Decontamination

Chair: Joseph Dudley
Co-Chair: Tim Wood

10.50 - 12.30

  • Aue, Walter (82)
    Covering Sources of Toxic Vapors with Foam
  • Kiel, Johnathan (83)
    Select Agent Recovery And Identification Using Aptamer-Linked Immobilized Sorbent Assay
  • Wood, Tim (84)
    The Comparison of a Commercially Available Anthrax Detection Kit with a Novel Sybr-Green Based Assay
  • Ribordy, Pascale (85)
    Mobile Decontamination Units In Sweden Are Not Effective      
  • Stienstra, Stef (86)
    Peroxide in Nanoparticles is an Effective Method to Disinfect Areas Contaminated with B-Agents      

12.30 - 13.30    Lunch
13.30                 Buses leave for farewell Tour and Dinner.  Will stop in Interlaken for accompanied persons.  Tickets have to be purchased for accompanied persons.


Friday 18 April 2008

07.45                 Buses leave from the hotels in Interlaken

Session 12 Biological Aspects II

Chair: Eddie Chang
Igor Dunaitsev

08.30 - 09.50

  • Chang,  Eddie (87)
    Metal-Ion Complexes as Potential new Broad-Spectrum Antiviral Drugs
  • Biketov, Sergey (88)
    Preparation and Characterization of Bacillus Anthracis High - Specific Spore Antigen
  • Kau, Jyh-Hwa (89)
    Antimicrobial Activity Of Visible Light-Illuminated Titania Photocatalysts Against Bacillus Anthracis
  • Mahboob, Sumera (90)
    Germa-γ-Lactones as New Pharmacological Agents: Anti-Leishmanial Effects and Epidemic Perspective of this Infection in Pakistan

Session 13  Emerging Threats, Dual Use, BioSafety/BioSecurity  II

Chair: David Trudil
Co-Chair: Harry Deneer

09.50 - 11.00

  • Trudil, David (91)
    Initiatives for Proliferation Prevention
  • Ioannis, Galatas / Leitner, Peter (92)
    Physical & Behavioral Signals for “Screeners” Indicating a Human Vector May Have Handled CBW Agents
  • Gareva, Radica (93)
    Asymmetric Threats of the 21st Century from the Strategic Management Perspective

11.00 - 11.30    Farewell Coffee

Session 14        The Closing Session:  Sector Chair Reviews of Sessions/Future Efforts

Chair: Brian Davey
Co-Chair: Barbara Price

11.30 - 12.30

  • Summary of Session contributions by Sector Chair Persons
  • Where should future CBMTS efforts be directed?
  • The CBMTS VII Closing

12.30 - 13.30    Farewell Lunch
13.45                 Buses leave to Interlaken
19.00                 Dinner at Hotel Metropole


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Updated by Evan Saunders, 16 March, 2008

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