ASA 10-4, Issue No. 139, August 27, 2010


Note: This paper was presented at CBMTS VIII, SPIEZ LABORATORY, 2-7 May 2010 and is part of the CBMTS VIII Proceedings which Prof. Urs Brodbeck is finalizing for publication by the SPIEZ LABORATORY. Our thanks to Prof. Biketov and the Obolensk crew and to Prof. Brodbeck for his untiring efforts.

The Search and Identification of the New Bacillus Anthracis Exosporium Antigen as Immunodiagnostic Target

Sergey Biketov, Eugenia Baranova, Igor Dunaytsev, Pavel Solov'ev and Ivan Dyatlov

State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow region, 142279, Russia

ABSTRACT

          Spores of Bacillus anthracis have been and are still important as a potential biowarfare agent. It is well known that the efficiency of medical countermeasures is dependent on the period of time within which the bioagent is identified. A direct and rapid spore detection by an antibodies based detection system is a very attractive choice among other methods including DNA-based assays or routine phenotyping, which usually are indirect, time-consuming and expensive. We developed immunochemical approaches to be used in anthrax species-specific spore biodetection.

Full Article


Ed. Note: Our thanks to Dr. Mike Rowell, Head OPCW Health and Safety and a member of the CBMTS, for providing the international ASA family this farewell from our best ASA and CBMTS family friend - the Ambassador. Mike with his own very time compressed schedule was able to work with Ambassador Rogelio Pfirter, the Director General of the Organiztrion for the Prohibition of Chemical Weapons (OPCW) and his very, very time compressed schedule.

Rogelio Pfirter's Farewell

          As the two-term Director-General for the OPCW prepares to leave office, he reflects on the achievements of the organisation and what the future holds.

          I arrived at the OPCW in 2002 after a significant bilateral and multilateral experience on a wide range of sensitive issues, including the non-proliferation of weapons of mass destruction (WMD).

Indeed by that time, as a career Argentine diplomat I had been already Ambassador to the United Kingdom, twice Undersecretary of Foreign Policy, the negotiator of Argentina's Nuclear Agreements with Brazil and the IAEA, the first Director of the Argentine-Brazilian Agency for the Accounting and Control of Nuclear Materials, a Director of the Argentine Space Agency, a leading promoter of my country's accession to the NPT and the Tlatelolco Treaty, and the drafter of Argentina's strict legislation regulating the export of sensitive materials. I had also been posted twice, for a total of 13 years, as a delegate at Argentina's Permanent Mission to the United Nations.

Ed. Note: Dr. Hua Li was formerly with the OPCW in The Hague and is now with the Institute of Pharmacology and Toxcology (IPT) in Beijing. Dr. Hua Li is a member of the Editorial Advisory Board of the Journal of Medical Chemical Biological and Radiological Defense (www.JMedCBR.org)

Detection of Ricin in Various Samples by Double Antibody Sandwich Enzyme Linked Immunosorbent Assay

Yuxia Wang, Hua Li
Beijing Institute of Pharmacology and Toxicology

Ricin is a protein toxin extracted from the castor bean plant Ricinus communis. This easily-available toxin [1,2] is a heterodimeric ribosome inactivating protein containing two chains. Ricin A chain (RTA) is a 267 amino acids N-glycosidase that hydrolyses a specific adenine residue from a highly conserved loop region of 28S rRNA a key step to inhibit protein synthesis [3,4]. Ricin B chain (RTB) is a galactose-specific lectin with 262 amino acids, which recognizes and interacts with the specific binding site on the cell surface and promotes the endocytotic uptake of the protein [5, 6].

an inside look at ASA 10-4

The Professional Library
2
BioSecurity: a new centre in Switzerland
3
Executive Summary Conclusion CBMTS VIII

5

Plants and Pathogen Resistance - dual use

9

Natick (NSRDEC) Thinking Ahead
9
ON THE STREET
13
JMed CBR Defense, ONLY Journal recognized
13
Johan Santesson's Vargtass - Wolf's Paw 15
The ORCHIDS Project 16
Health Notes for ASA/CBMTS 17
National Strategy for Countering Bio Threats 18
M291 SDKs and continued use?
19
Industry Note 20
The HULC 21
Recent Contracts
21
BioScope‘10
28
 
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